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作者检测了60例6个月至3岁零8个月营养不良儿童的外周血T细胞亚群,结果表明:中、重度营养不良伴血锌降低;轻度营养不良患儿外周血全T细胞(OKT_3~+)、T辅助/诱导T细胞(OKT_4~+)、T抑制/细胞毒T细胞(0KT_3~+)低于正常。0KT_3~+、OKT_4~+细胞随营养不良程度的加重,其下降更明显。中、重度营养不良合并感染时,0KT_3~_+、0KT_4~+及OKT_4~+/OKT_8~+细胞比值明显低于无感染组,提示细胞免疫的主要效应及调节细胞受损。OKT_3~+、OKT_4~+细胞可作为早期检测营养不良患儿免疫功能有无受损的灵敏指标。
The authors tested the 60 T-cell subsets in peripheral blood of 60 malnutrition children from 6 months to 3 years and 8 months of age. The results showed that moderate and severe malnutrition with decreased serum zinc; peripheral blood total T cells in children with mild malnutrition (OKT_3 ~ +), T helper / induced T cells (OKT_4 ~ +), T suppressor / cytotoxic T cells (0KT_3 ~ +) were lower than normal. 0KT_3 ~ +, OKT_4 ~ + cells with the degree of malnutrition, the decline is more obvious. The ratio of 0KT_3 ~ _ +, 0KT_4 ~ + and OKT_4 ~ + / OKT_8 ~ + was significantly lower than that of the non-infected group, indicating the main effect of cellular immunity and the regulation of cell damage. OKT_3 ~ +, OKT_4 ~ + cells can be used as early detection of malnutrition in children immune function with or without sensitivity indicators.