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目的探讨抑癌基因PTEN蛋白和Caspase-3在骨肉瘤中的表达及在其发生发展中的可能作用。方法用免疫组织化学方法检测PTEN和Caspase-3在38例骨肉瘤及20例骨软骨瘤中的表达。结果PTEN蛋白在骨肉瘤中,表达阳性率为55.3%。在对照组骨软骨瘤中为90.0%,骨肉瘤与骨软骨瘤相比有显著差异(P<0.01)。Caspase-3在骨肉瘤中表达阳性率为52.6%,在对照组骨软骨瘤中为85.0%,骨肉瘤与骨软骨瘤相比有显著差异(P<0.05)。结论PTEN蛋白和Caspase-3与骨肉瘤的发生有关。
Objective To investigate the expression of tumor suppressor gene PTEN and Caspase-3 in osteosarcoma and its possible role in the development of osteosarcoma. Methods The expressions of PTEN and Caspase-3 in 38 osteosarcomas and 20 osteochondroma were detected by immunohistochemistry. Results The positive rate of PTEN protein in osteosarcoma was 55.3%. There were significant differences between osteosarcoma and osteochondroma in control group (90.0%) (P <0.01). The positive rate of Caspase-3 expression in osteosarcoma was 52.6%, which was 85.0% in osteochondroma of control group. There was significant difference between osteosarcoma and osteochondroma (P <0.05). Conclusions PTEN protein and Caspase-3 are associated with the occurrence of osteosarcoma.