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目的探讨哮喘急性发作期患儿吸入福莫特罗后起效时间和及即刻肺功能变化。方法能掌握肺功能测定方法及都保吸入方法的急性发作支气管哮喘患儿52例,测基础肺功能,随机分为A组吸入福莫特罗4.5μg,B组吸入9.0μg,吸药3～5min后复查肺功能。结果两组吸药后第1秒用力呼气肺活量占预计值的百分比(FEV1%)、呼气峰流速占预计值的百分比(PEF%)及最大呼气中段流速占预计值的百分比(MMEF%)均有明显改善(P均<0.05)。B组吸药后肺功能改善较A组更显著。结论福莫特罗起效迅速,可快速缓解哮喘症状。
Objective To investigate the onset time and immediate pulmonary function changes of inhaled formoterol in children with acute exacerbation of asthma. Methods Fifty-two children with bronchial asthma were randomly divided into group A with inhalation of formoterol 4.5μg, group B with inhalation 9.0μg, Pulmonary function after 5min review. Results The FEV1% of forced expiratory volume in the first two seconds after inhalation of the two groups were as predicted (PEF%), and the percentage of the maximum expiratory flow rate to the predicted value (MMEF% ) Were significantly improved (P all <0.05). B group after inhalation of lung function improved more significantly than the A group. Conclusion Formoterol has a rapid onset of action and can rapidly relieve asthma symptoms.