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从神经化学的角度讲,震颤性麻痹是以脑组织中多巴胺能系统的紊乱为特征的。多巴胺能系统包括多巴胺、多巴胺的代谢终结产物3甲氧—4羟苯乙酸(高香草酸 homovanillic acid)、酪氨酸羟化酶、左旋多巴脱羧酶等。而多巴胺能系统的紊乱是由于黑质纹状体多巴胺神经通路的退行性变。许多原因如脑炎后,老年性动脉硬化,慢性锰中毒,神经麻痹药物以及所谓特发性原因等都能引起纹状体多巴胺的缺乏而出现震颤性麻痹。因此作者提出“纹状体多巴胺缺乏综合症”这一新的概念,而且用一种新的高疗效药物来治疗震颤性麻痹,此药即左旋多巴,它是多巴胺的前身,和多巴胺不同者此药能通过血脑屏障。所以左旋多巴疗法实质上是多巴胺替代疗法,病人长期大量
From a neurochemical point of view, tremor paralysis is characterized by disorders of the dopaminergic system in the brain. Dopaminergic systems include dopamine, the metabolic end products of dopamine, 3-hydroxy-4-hydroxyphenylacetic acid (homovanillic acid), tyrosine hydroxylase, levodopa decarboxylase and the like. The disorder of the dopaminergic system is due to degeneration of the nigrostriatal dopamine neural pathway. Many reasons, such as post-encephalitis, senile arteriosclerosis, chronic manganese poisoning, nerve palsy drugs and so-called idiopathic causes can cause striatal dopamine deficiency appear tremor paralysis. The authors therefore proposed the new concept “Striatal dopamine deficiency syndrome” and treated tremor paralysis with a new and highly effective drug, levodopa, which is the predecessor of dopamine and differs from dopamine This medicine can cross the blood-brain barrier. So levodopa therapy is essentially dopamine replacement therapy, a large number of patients in the long term