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目的探讨2%利拉萘酯乳膏治疗体股癣、足癣的临床疗效和安全性。方法采用多中心随机双盲阳性药平行对照法,分别在3个中心进行,入选288例患者,2%利拉萘酯乳膏试验组144例,1%联苯苄唑乳膏对照组144例;每组中体股癣患者各72例,足癣患者各72例。每日涂药1次,足癣疗程4周,每2周复诊1次;体股癣疗程2周,每周复诊1次;停药后2周均再复诊1次。结果试验组体股癣患者中有1例脱落。停药时体股癣试验组的痊愈率和有效率分别为59.2%和94.4%,足癣试验组分别为41.7%和81.9%,与对照组比较,差异均无统计学意义(P>0.05)。在用药结束后2周时,体股癣试验组的痊愈率和有效率分别为67.6%和94.4%,足癣试验组分别为54.2%和81.9%,与对照组比较,差异无统计学意义(P>0.05)。在用药结束后2周,体股癣和足癣试验组符合方案分析集真菌学清除率分别为97.18%和90.28%,试验组和对照组差异均无统计学意义(P>0.05)。用药后发生的不良反应表现为用药部位红肿、疼痛,其中体股癣试验组不良反应发生率为2.78%。结论2%利拉萘酯乳膏治疗体股癣、足癣有良好的疗效和安全性。
Objective To investigate the clinical efficacy and safety of 2% liraglutide cream in the treatment of tinea corporis and tinea pedis. Methods A multicenter randomized, double-blind, positive drug parallel control was performed in 3 centers. Of the 288 patients, 144 were treated with 2% liranapyr ester cream and 144 were treated with 1% bifonazole cream. In each group, there were 72 cases of tinea corporis and 72 cases of tinea pedis. 1 times a day, tinea pedis 4 weeks treatment, referral every 2 weeks 1; body ringworm treatment 2 weeks, weekly referral 1; 2 weeks after stopping the repeat referral 1 times. Results The experimental group tinea cruris in 1 case off. The cure rate and effective rate of tinea corporis test group were 59.2% and 94.4% when the medicine was withdrawn, 41.7% and 81.9% for the tinea pedis test group, respectively, with no significant difference compared with the control group (P> 0.05) . At 2 weeks after the end of medication, the cure rate and effective rate of body ring tinea test group were 67.6% and 94.4%, respectively, and the tinea pedis test group was 54.2% and 81.9% respectively, with no significant difference compared with the control group P> 0.05). At 2 weeks after the end of medication, mycotic clearance rate of the tinea corporum and tinea pedis test group was 97.18% and 90.28%, respectively. There was no significant difference between the experimental group and the control group (P> 0.05). Adverse reactions after treatment manifested as swelling and pain in the site of treatment, in which the incidence of adverse reactions in body tinea test group was 2.78%. Conclusion 2% liraglutide cream for the treatment of tinea corporis and tinea pedis have good curative effect and safety.