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采用受体的放射配基结合分析法(RLBA)测定20例喉癌、26例喉息肉、10例喉乳头状瘤患者肿瘤组织的雌激素受体(ER)和孕激素受体(PR)含量。结果发现,喉癌组织中胞核ER,胞浆、胞核PR含量均高于喉息肉和喉乳头状瘤,差异有显著性(P<0.01)。喉癌Ⅱ期和Ⅲ期胞核PR含量高于喉癌Ⅰ期胞核,差异有显著性(P<0.05)。提示:ER和PR与喉癌可能有一定的依赖关系;ER和PR在喉癌的发生、发展中可能起重要作用;PR与喉癌的分期有相关性。
The levels of estrogen receptor (ER) and progesterone receptor (PR) in 20 cases of laryngeal cancer, 26 cases of laryngeal polyps and 10 cases of laryngeal papilloma were measured by radioligand binding assay (RLBA) . The results showed that the contents of ER, cytoplasm and nucleus PR in laryngeal carcinoma tissues were significantly higher than those in laryngeal polyp and laryngeal papilloma (P <0.01). The levels of PR in nucleus of stage Ⅱ and Ⅲ in laryngeal carcinoma were higher than those in laryngeal carcinoma stage Ⅰ (P <0.05). It is suggested that ER and PR may have a certain dependence on laryngeal cancer; ER and PR may play an important role in the occurrence and development of laryngeal cancer; PR has correlation with staging of laryngeal cancer.