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重症肌无力症,病因目前已基本明确,乃是自体免疫反应引起神经、肌肉接头处突触后膜上胆碱受体(AchR)破坏,由于受体数量上减少,或敏感性低下,当递质(乙酰胆碱)释放量稍有减少,即出现肌肉无力,甚至麻痹。既往对本病以抗胆碱脂酶药物治疗为主,近年来针对免疫病因,开始采用免疫抑制剂,其中间日顿服大剂量强地松疗法,国外早有报告,国内亦有介绍,但是系统性环磷酰胺治疗,国内报道不多,兹就我们治疗的5
Myasthenia gravis, the cause has been basically clear, but the autoimmune reaction caused by neuromuscular junction of the postsynaptic membrane cholinergic receptors (AchR) damage due to the receptor number decreased, or the sensitivity is low, when the delivery Mass (acetylcholine) release slightly reduced, that muscle weakness, or even paralysis. In the past, the disease was mainly treated with anti-cholinesterase drugs. In recent years, immunosuppressants have been used in immunosuppressive therapy. Among them, the middle dose of Dayton-affirmed high-dose prednisone therapy has been reported in foreign countries as well as in China Systemic cyclophosphamide treatment, reported few domestic, it is our treatment 5