目的探讨VIII因子相关抗原(VIII-RAg)、基质金属蛋白酶9(MMP-9)与米非司酮药物流产(药流)后子宫异常出血的相关性。方法采用免疫组织化学法,对正常早孕人工流产(人流组)、药流完全和不完全组蜕膜组织中VIII-RAg和MMP-9进行标记,应用图像分析仪对标记结果进行定量观察,SPSS10.0统计软件进行数据分析。结果药流完全组和药流不全组出血区与人流组和药流不全组无出血区比较,蜕膜血管内皮细胞VIII-RAg和基质细胞MMP-9的表达,均有显著性差异(P<0.01),而药流完全组和药流不全组出血区之间,人流组和药流不全组无出血区之间无显著差异。结论米非司酮药流后子宫异常出血与蜕膜血管内皮VIII-RAg和基质细胞MMP-9的表达异常相关。 Objective To investigate the relationship between factor VIII-related antigen (VIII-RAg), matrix metalloproteinase 9 (MMP-9) and abnormal uterine bleeding after mifepristone abortion (drug abortion). Methods Immunohistochemical method was used to mark VIII-RAg and MMP-9 in normal abortion (abortion group), complete abortion group and incomplete decidual tissue in abortion group. Quantitative observation of the labeling results was performed by image analyzer, SPSS10. 0 statistical software for data analysis. Results There were significant differences in the expression of VIII-RAg and MMP-9 in the decidual vascular endothelial cells between the complete abortion group and the incomplete abortion group and the no abortion group and the inferior abortion group (P <0.01) However, there was no significant difference between the abortion group and the abortion group without hemorrhage between the complete abortion group and the incomplete abortion group. Conclusion Abnormal uterine bleeding after mifepristine abortion is related to abnormal expression of VIII-RAg in decidual endothelium and MMP-9 in stromal cells.