调节性T细胞(regulatory T cell,Treg)是一群发挥免疫抑制功能的淋巴细胞,在维持机体内环境稳定、预防自身免疫病、控制移植排斥中发挥重要作用,但却抑制了机体的抗肿瘤免疫。最近几年,有关Treg作为肿瘤的免疫治疗的靶细胞研究很多,本综述总结了这些研究的新进展,分析通过抑制Treg进行肿瘤免疫治疗的各种手段以及存在的隐患。 Regulatory T cell (Treg) is a group of immunosuppressive lymphocytes that play an important role in maintaining the stable environment, preventing autoimmune diseases and controlling graft rejection, but inhibiting the body’s anti-tumor immunity . In recent years, there are many researches on Treg as target cells for immunotherapy of tumors, and in this review, we summarize the new progress of these studies and analyze various means and potential risks of tumor immunotherapy by inhibiting Tregs.