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实验研究证实，中药三花丹对小鼠S－180肿瘤及肝癌实体瘤具有显著的抑制作用（P＜0．02~0．01）。S－180肿瘤及肝癌实体瘤抑瘤率平均分别为：环磷酸胶组59．45％与54．86％；三龙丹大剂量组66．74％与53．62％；三龙丹小剂组56．05％与48．72％。三次实验结果基本一致，重复效果稳定。病理组织检验提示，阴性对照组癌细胞生长活跃，呈片状分布，浸及脂肪结缔组织深达肌层。环磷酸胺组癌细胞浸润深度同阴性对照组，但癌组织中可见灶状坏死。中药三龙丹组癌组织坏死面积广泛，仅可见部分残留的癌细胞，其中大剂量组明显优于环磷酰胺组。临床典型病人3例，通过病理组织活俭及CT检验证实，2例治愈，1例显效，均存活至今。
Experimental studies confirmed that Sanhua Dan had a significant inhibitory effect on S-180 tumors and solid tumors of liver cancer (P<0.02-0.01). The average tumor inhibition rates of S-180 tumors and solid tumors of hepatocellular carcinoma were 59.45% and 54.86% in the cyclic phosphate gel group, 66.74% and 53.62% in the Sanlongdan high-dose group, respectively; Group 56.05% and 48.72%. The results of the three experiments were basically the same, and the repeat effect was stable. Histopathological examinations revealed that the cancer cells in the negative control group grew actively, showing a patchy distribution, and the connective tissue of the adipose and adipose tissue reached deep into the muscularis. The depth of cancer cell infiltration in the cyclic phospho-amine group was the same as that in the negative control group, but focal necrosis was seen in the cancerous tissue. The area of necrosis of the cancerous tissue in the Sanlongdan group of traditional Chinese medicine is extensive, only some residual cancer cells are visible, and the high-dose group is significantly superior to the cyclophosphamide group. Clinically typical patients in 3 cases, confirmed by pathological tissue live sputum and CT examination, 2 cases were cured, 1 case was markedly effective, and all survived to this day.