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目的:评价腔内介入手术治疗中重度肾动脉狭窄的单中心近中期疗效。方法:回顾性分析2013年1月至2019年3月天津医科大学总医院收治的79例中重度肾动脉狭窄患者的临床资料，比较分析术前与术后血压、血肌酐（Scr）、肾小球清除率（eGFR）及降压药服用种类的差异。结果:79例患者均顺利完成腔内介入手术，技术成功率为100%，无术中并发症，无死亡病例。随访时间为（31.0±23.1）个月（范围：1~75个月），非手术相关死亡2例。随访期并发症4例（5.1%，4/79），包括1例继发肾功能不全，3例靶病变处支架再狭窄，此3例均行二次球囊扩张术。术后6个月，收缩压及舒张压[（139±20）mm Hg，（85±11）mm Hg]低于术前[（185±26）mm Hg,（106±14）mm Hg]，差异有统计学意义（n P均0.05]。n 结论:腔内介入手术治疗中重度肾动脉狭窄近中期生存率高，并发症发生率低，可以有效降低患者血压及减少服用降压药物种数，但对患者肾功能并无明显改善。“,”Objective:To evaluate early and mid-term effects of endovascular therapy for moderate to severe renal artery stenosis.Methods:The clinical data of patients with moderate to severe renal artery stenosis from January 2013 to March 2019 in Tianjin Medical University General Hospital were collected, the preoperative and postoperative blood pressure, serum creatinine (Scr) , estimated glomerular filtration rate (eGFR) , and types of anti-hypertensive drugs were compared retrospectively.Results:Seventy-nine patients were successfully treated with stenting or ballooning, achieving a technical success rate of 100%, without any operative complications. The patients were followed up for (31.0±23.1) months (range: 1-75 months) . There were 2 non-operation-related deaths during the follow-up. The incidence of complications was 5.1% (4/79) , including renal failure in 1 patient after operation and restenosis of the stent at target lesion in 3 patients treated by reoperation. Systolic blood pressure declined from (185±26) mm Hg to (139±20) mm Hg (n P0.05) . The types of anti-hypertension drugs declined from 1.94±1.20 to 1.50±1.08 (n P=0.020) .n Conclusion:Endovascular therapy for renal artery stenosis is an efficient and safe operation, with high survival rate and low complication rate in early and mid-term after operation. It can effectively reduce blood pressure and types of anti-hypertensive drugs, though renal function of patients is not significantly improved.