糠秕马拉色菌属(Malassezia)主要为一些亲脂性的双相酵母菌,生长于人类皮肤的角质层,与皮肤表面存在的三酸甘油酯、游离脂肪酸等脂质及皮脂腺有关,能引起花斑癣和脂溢性皮炎,但至今对于它们的侵袭方式及感染过程还了解不多。作者应用活体皮肤等同物(LSE)研究糠秕马拉色菌早期的定植和酵母到菌丝相的转换。即将糠秕马拉色菌(M.furfur)培养于人类角朊细胞上,而后者则置于液态真皮等同 Malassezia is a family of lipophilic, biphasic yeast that grows in the stratum corneum of human skin and is associated with lipids such as triglycerides and free fatty acids on the surface of the skin and sebaceous glands that cause flowers Tinea versicolor and seborrheic dermatitis, but little is known about how they are affected and the course of the infection so far. The authors used live skin equivalents (LSE) to study the early colonization of Malassezia furfur and the conversion of yeast to mycelial phases. M. furfur was cultured on human keratinocytes, while the latter was placed in liquid dermis equivalent