皮质类固醇引起永久性脑病报告较少,现报告一例如下:女性,65岁,教师。因关节肿痛,低烧,入院。采用10%葡萄糖注射液500ml+地塞米松10mg 静滴,次日清晨三点钟,患者出现手乱摸,语无伦次,重复语言,头痛、呕吐,又哭又笑等精神症状。2日后病情进一步发展,患者出现神志不清,失语,大小便失控。经CT 检查诊断为多发性脑梗塞.体检:神志不清,营养发育尚好,左侧鼻唇沟变浅,左侧偏瘫,肌力Ⅰ级,肌张力普遍增高,腱反射亢进,以左侧为甚。右侧霍夫曼和掌颏反射阳性.眼底检查视乳头反光度增强,视乳头颞侧的边缘模 Corticosteroids cause fewer reports of permanent encephalopathy. One report is as follows: Female, 65 years old, teacher. Because of joint swelling and pain, fever, admission. Using 10% glucose injection 500ml + dexamethasone 10mg intravenous infusion, three o’clock in the morning the next day, patients hand touch, incoherent, repeat language, headache, vomiting, crying and laughing and other mental symptoms. 2 days later the disease further development, patients appear unconscious, aphasia, urine loss of control. The diagnosis of multiple cerebral infarction by CT examination. Physical examination: delirium, nutrition development is good, the left nasolabial fold shallow, left hemiplegia, muscle strength grade Ⅰ, muscle tension generally increased tendon hyperreflexia to the left very. Huffman and chin on the right side of the reflex positive.The fundus examination increased visual acuity of the optic nerve, the temporal mold of the optic nerve