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已知肿瘤放、化疗造成的造血功能抑制是肿瘤治疗失败的主要原因。此外,无论是实体或血液肿瘤,其持续生长都必须依赖新生血管的形成,因此本项目从造血保护和抗肿瘤血管新生两方面着手,研究探索新的抗肿瘤治疗技术,着重研究:降低造血干细胞对化疗药物和辐射的敏感性,阻止化疗药物和辐射引起的造血细胞凋亡,从而可以增大治疗剂量,最大限度地杀死肿瘤细胞而不引起造血功能严重受损;刺激造血干细胞的增殖、粘附和归巢,促使造血全面恢复;抑制肿瘤血管新生,阻断营养血管导致肿瘤细胞缺血性坏
Known tumor radiotherapy, chemotherapy-induced hematopoietic suppression is the main reason for the failure of cancer treatment. In addition, both solid and hematological tumors must rely on the formation of neovasculature for their sustained growth. Therefore, this project aims to explore new antitumor therapeutic techniques from the perspectives of hematopoietic protection and antiangiogenic angiogenesis. Emphasis will be placed on reducing the number of hematopoietic stem cells The sensitivity to chemotherapeutic drugs and radiation prevents the apoptosis of hematopoietic cells caused by chemotherapeutic drugs and radiation, thereby increasing the therapeutic dose, killing the tumor cells to the maximum extent without causing serious damage to the hematopoietic function, stimulating the proliferation of hematopoietic stem cells, Adhesion and homing, prompting a full recovery of hematopoiesis; inhibition of tumor angiogenesis, blocking of nutrient vessels leading to tumor cell ischemic damage