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1、一次腹腔注入硝酸铀酰(每公斤体重5及2.5毫克)溶液后,大白鼠肾小管上皮细胞的坏死首先并主要发生在近曲管第2段:最早发现变化的时间是中毒后6—12小时。其次是近曲管的第3段。 2、急性铀中毒时近曲管上皮细胞早期损害的形式可随所在节段而异:在第2段为肾小管完全坏死,第3段则主要表现为胞浆疏松、水泡性变、蛋白滴沉着和肾小管不全坏死。 3、急性铀中毒时可以出现近曲管颈部向肾小球囊腔内突入返折、Henle氏细枝管型充填、Henle氏粗枝上皮糖元沉着和肾脏动脉中膜变性。此外,个别动物曾发生肾脏动脉的血 栓形成性坏死性动脉炎和肾脏梗死。上述病变均不见于既往的有关文献资料。
1, an intraperitoneal injection of uranyl nitrate (per kg of body weight 5 and 2.5 mg) solution, the necrosis of renal tubular epithelial cells in rats first and mainly occurred in the second paragraph of the proximal tubule: the earliest time to change was toxic 6- 12 hours. Followed by the third song near the tube. 2, acute uranium poisoning near the early damage of the testicular epithelial cells in the form may vary with the segment where: in the second paragraph of renal tubular necrosis, the third paragraph of the main manifestations of loose cytoplasm, vesicular changes, protein droplets Calm and tubular necrosis. 3, acute uranium poisoning can occur near the neck into the glomerular cyst into the fold, Henle’s prickly tubular filling, Henle’s rough branches glycogen deposition and renal arterial membrane degeneration. In addition, thrombotic necrotizing arteritis and renal infarction of renal arteries have occurred in individual animals. The above lesions are not seen in the previous literature.