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通过记录个别T细胞不一样的命运,研究人员证实可以有效模拟出适应性免疫反应从前不可预知的一些方面。即一个至关重要的问题:是什么决定了免疫系统数以百万计的细胞中,哪些细胞将动员起来对抗急性感染?哪些细胞则留在后方长期存活,形成了免疫记忆的基础?科学家们的研究发现发表在《科学》(Science)杂志上,有可能对改善免疫治疗和疫苗接种策略产生影响。科学家们发现,一小部分能够识别相关抗原的CD8+T细胞,启动了对于感染或肿瘤的直接免疫反应。这小部分细胞中的少数细胞快速扩增
By documenting the different fate of individual T cells, researchers have demonstrated some of the previously unpredictable aspects of the adaptive immune response that can be effectively mimicked. One of the most important questions is: What determines the immune system? Of the millions of cells, which cells mobilize against acute infection? Which cells remain behind for long-term survival and form the basis of immune memory? Scientists The findings, published in Science, are likely to have implications for improving immunotherapy and vaccination strategies. Scientists have found that a small percentage of CD8 + T cells that recognize the antigen of interest initiate an immediate immune response to the infection or tumor. A small number of cells in this small number of cells rapidly proliferate