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目的探讨检测血浆N末端脑利钠肽前体(NT-proBNP)、脑利钠肽(BNP)、醛固酮(Ald)评估2型糖尿病(T2DM)肾病的临床意义。方法 85例T2DM患者分为糖尿病无肾病组(A组,40例)和糖尿病肾病组(B组,45例),健康体检者20例作为正常对照组(C组)。采用电化学发光法(ECL)、微粒子化学发光法(CLIA)及放射免疫法(RIA)分别检测三组血浆NT-proBNP、BNP和Ald水平。结果与C组比较,A组和B组NT-proBNP、BNP水平明显升高(P<0.05),而Ald明显降低(P<0.05)。与A组比较,B组NT-proBNP、BNP水平明显升高(P<0.05),而Ald明显降低(P<0.05)。结论检测血浆NT-proBNP、BNP和Ald可以作为评估T2DM肾病患者心功能状态和预后的指标。
Objective To investigate the clinical significance of detecting plasma N-terminal pro-brain natriuretic peptide (NT-proBNP), brain natriuretic peptide (BNP) and aldosterone (Ald) in the diagnosis of type 2 diabetes mellitus (T2DM) Methods Totally 85 patients with T2DM were divided into diabetic nephropathy group (A group, 40 cases) and diabetic nephropathy group (B group, 45 cases), and 20 healthy subjects were selected as normal control group (C group). Plasma levels of NT-proBNP, BNP and Ald were detected by ECL, CLIA and RIA respectively. Results Compared with group C, the levels of NT-proBNP and BNP in group A and B were significantly increased (P <0.05), while Ald was significantly decreased (P <0.05). Compared with group A, the levels of NT-proBNP and BNP in group B were significantly increased (P <0.05), while Ald was significantly decreased (P <0.05). Conclusion The detection of plasma NT-proBNP, BNP and Ald can be used as indicators to evaluate the cardiac function and prognosis of patients with T2DM.