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目的:探讨血清肿瘤坏死因子-α(TNF-α)和白介素-10(IL-10)浓度变化在重症脓毒症患者预后评估中的应用。方法:采用酶联免疫吸附法C(ELISA法)对97例重症脓毒症患者入ICU时的血清TNF-α、IL-10进行测定,根据患者预后效果将97例患者分为生存组和死亡组,对比分析两组TNF-α和IL-10的变化;同时选取同期健康体检者30例设对照,观察脓毒症组与对照组血清TNF-α和IL-10的水平差异。结果:重症脓毒症患者入ICU首日TNF-α和IL-10水平明显高于健康对照组(P<0.05);死亡组存活组比较,TNF-α和IL-10的表达明显增加,差异有统计学意义(P<0.01)。结论:TNF-α和IL-10在重症脓毒症的发生发展中起着重要作用,为脓毒症患者预后评估及治疗的选择提供理论依据。
Objective: To investigate the application of serum tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10) in the prognosis assessment of severe sepsis patients. Methods: The levels of serum TNF-α and IL-10 in 97 severe sepsis patients admitted to ICU were determined by enzyme-linked immunosorbent assay (ELISA). 97 patients were divided into survival group and death according to the prognosis of patients The levels of TNF-α and IL-10 in sepsis group and control group were observed and compared. The changes of TNF-α and IL-10 in two groups were compared. Results: The levels of TNF-α and IL-10 on the first day after ICU admission in patients with severe sepsis were significantly higher than those in healthy controls (P <0.05). The expression of TNF-α and IL-10 in survival group were significantly increased There was statistical significance (P <0.01). Conclusion: TNF-α and IL-10 play an important role in the development of severe sepsis and provide a theoretical basis for the prognosis assessment and treatment of patients with sepsis.