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近年来研究表明,肿瘤患者体内存在免疫功能障碍.已知肝癌患者NK细胞活性降低,淋巴细胞业群失散.为探讨原发性肝癌肝动脉栓塞化疗同时灌注IL-2、TNF-α对机体免疫功能的影响,本研究检测了22例肝癌患者灌注lL-2、TNF-α治疗前后的T淋巴细胞亚群,NK细胞活性,自身LAK细胞活性,slL-2R及IL-1、IL-8和TNF-α等细胞因子活性,并与单纯栓塞化疗组加以比较,现报道结果如下.1 材料与方法1.1病例选择原发性肝癌患者42冽,全部病例均行B超、CT及MRI检查显示有肝内占位性病变.男36例,女6例,年龄32～70岁,平均年龄52.6岁.肝动脉栓塞化疗同时灌注IL-2、TNF-α组22例,简称细胞因子治疗组.单纯栓塞化疗组20例,分别于治疗前和疗程
In recent years, studies have shown that immunological dysfunction exists in patients with cancer. NK cell activity in patients with known liver cancer decreased, lymphocyte industry group was lost. In order to explore the hepatic artery embolization chemotherapy in primary hepatic artery perfusion IL-2, TNF-α immune In terms of function, this study examined the T lymphocyte subsets, NK cell activity, autologous LAK cell activity, slL-2R, IL-1, IL-8, and IFN-α infusion in patients with liver cancer before and after treatment. TNF-α and other cytokine activities were compared with the simple embolization chemotherapy group. The results are reported as follows.1 Materials and methods 1.1 Cases Primary hepatocellular carcinoma patients were selected for 42 冽. All cases were examined by ultrasound, CT, and MRI. Intrahepatic space-occupying lesions, 36 males and 6 females, aged 32 to 70 years, mean age 52.6 years. Hepatic artery embolization chemotherapy infusion of IL-2, TNF-α group 22 cases, referred to as cytokine therapy group. 20 cases of embolization chemotherapy group before and after treatment