多年来发现在胰岛素非依赖型糖尿病惠者服用磺脲类药物期间对酒精敏感。1978年英国学者lesile、pyke设计一种试验,在服用氯磺丙脲的基础上服用sherry,在一小时内可见部分患者头颈部皮肤温度升高,主观热感,即为氯磺丙脲酒精潮红试验阳性。阳性者大血管病变、微血管病变、周围神经病变的并发症明显较低。后来发现此现象与影响前列腺素合成、脑啡肽代谢及遗传因素有关,从而可以揭示糖尿病的病因学、并发症发病学,并可作为评价糖尿病治疗、予后的线索。我们吸取众家之长,部分改进,作了初步尝试。 Over the years it has been found to be alcohol sensitive during the administration of sulfonylureas to insulin-independent diabetes mellitus. In 1978, British scholar lesile, pyke designed a trial to take sherry on the basis of taking chlorpropamide, which showed that in some patients, the temperature of the skin of head and neck increased in some hours and the subjective feeling was that of chlorpropamide alcohol Flush test positive. Positive major macrovascular disease, microvascular disease, peripheral neuropathy complications were significantly lower. Later found that this phenomenon and the impact of prostaglandin synthesis, enkephalin metabolism and genetic factors, which can reveal the etiology of diabetes, the pathogenesis of complications, and can be used as the evaluation of diabetes treatment, post-clues. We learn from the public, some improvements, made a preliminary attempt.