Cancer and neurodegeneration include a group of diseases that are mechanistically distinct but may share common therapeutic targets.Autophagy is a common quality control mechanism shared by mitotic and post-mitotic cells and it can be exploited to accelerate clearance of unwanted oncogenes and reduce accumulation of toxic proteins in cancer and neurodegeneration,respectively.Tyrosine kinase inhibition is a therapeutically rele- Cancer and neurodegeneration include a group of diseases that are mechanistically distinct but may share common therapeutic targets. Autophagy is a common quality control mechanism shared by mitotic and post-mitotic cells and it can be exploited to promote clearance of unwanted oncogenes and reduce accumulation of toxic proteins in cancer and neurodegeneration, respectively. tyrosine kinase inhibition is a therapeutically rele-