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目的探讨白细胞的活动在慢性脑灌注不足脑损害中的作用。方法４０只老龄大鼠持久性双侧颈总动脉结扎（２ＶＯ），免疫组化法单抗 ＯＸ１抗白细胞共同抗原标记白细胞，实验研究为持久性２ＶＯ１～４月。结果持久性２ＶＯ后皮层、海马和白质处均有显著的白细胞活动。１—４月，皮层、海马和白质处白细胞的活动均明显减少，而脑损害却加重。结论白细胞的活动涉及大鼠慢性脑灌往不足脑损害的病理过程，但白细胞的活动在大鼠慢性脑灌注不足脑损害，特别是大脑白质损害中仅起次要作用。
Objective To investigate the role of leukocyte activity in chronic cerebral hypoperfusion brain damage. Methods Persistent bilateral common carotid artery ligation (2VO) was performed in 40 old rats. OX1 anti-leukocyte antigen was labeled with leukocyte antigen by immunohistochemistry. The experimental study was permanent for 2 months from 1 to 4 months. Results Persistent 2VO after the cortex, hippocampus and white matter were significant leukocyte activity. From January to April, the activities of cortical, hippocampal and white matter leucocytes were significantly reduced, while the brain damage was aggravated. Conclusion The activity of leukocytes is involved in the pathological process of chronic cerebral hypoperfusion in rats. However, leukocyte activity only plays a secondary role in the brain damage of chronic cerebral hypoperfusion in rats, especially the white matter damage of the brain.