本文给Wistar系大鼠单次腹腔注射野百合碱50 mg/kg,经过3周引起了肺动脉高压伴有右室肥大。在腹腔注射野百合碱后24h开始灌胃给硝苯吡啶,每天二次,每次5mg/kg、10mg/kg或30mg/kg可显著地减轻野百合碱所致的肺动脉压升高和右室肥大。提示硝苯吡啶长期给药有抑制野百合碱形成肺动脉高压的作用。 A single intraperitoneal injection of monocrotaline 50 mg/kg was given to Wistar rats. Pulmonary hypertension with right ventricular hypertrophy was induced after 3 weeks. Intraperitoneal injection of monocrotaline 24h after gavage to nifedipine, twice a day, each time 5mg/kg, 10mg/kg or 30mg/kg can significantly reduce the pulmonary artery pressure caused by monocrotaline and right ventricle Hypertrophy. It is suggested that long-term administration of nifedipine inhibits the formation of pulmonary hypertension in monocrotaline.