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[目的]了解瘦素在胎儿及婴幼儿生长发育中的作用.[方法]从电脑检索有关瘦素与胎儿至婴幼儿生长发育相关的文献进行综述.[结果]由脂肪细胞合成分泌的瘦素不仅与成人的体脂肪密切相关,而且对胎儿的体脂肪关系也很密切.不仅与胎儿的体脂肪生长发育相关,而且还与胎儿的体质指数以及体细胞、造血细胞、神经细胞的生长发育相关.新生儿期开始几天血中瘦素下降,新生儿体重下降,紧接着血中瘦素增多,新生儿体脂肪和体质指数也增高.婴幼儿期体脂肪量和体质指数随着瘦素改变而改变.[结论]瘦素参与胎儿至婴幼儿的体脂肪量及其生长发育的调节.
[Objective] To understand the role of leptin in the growth and development of fetus and infants. [Methods] The literature about the leptin related to the growth and development of fetus to infants was reviewed. [Results] The leptin Not only is it closely related to adult body fat, but also has a close relationship with fetal body fat, which is not only related to fetal body fat growth and development, but also related to fetal body mass index and the growth and development of somatic cells, hematopoietic cells and nerve cells .In the first few days of newborn blood leptin decreased, newborn weight decreased, followed by increased blood leptin, neonatal body fat and body mass index also increased.Fatty body mass and body mass index as infants and young children with leptin changes [Conclusion] Leptin is involved in the regulation of body fat mass and its growth and development from fetus to infants.