致命的全身性真菌感染仍是临床的一个重大问题,特别是在免疫功能受损的患者。最常见的致命真菌有念珠菌属、曲霉菌属和新型隐球菌属,它们可对临床常用的抗真菌药耐药。voriconazole(UK109496)是一个新的口服有效的三唑衍生物类抗真菌药,其抗菌谱广,在体外和体内对多种致病真菌 Fatal systemic fungal infections remain a major clinical problem, especially in patients with impaired immune function. The most common deadly fungi are Candida, Aspergillus and Cryptococcus neoformans, which are resistant to commonly used antifungal agents. Voriconazole (UK109496) is a new, orally active, triazole derivative antifungal agent with broad antibacterial spectrum against various pathogenic fungi in vitro and in vivo