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为了探讨肿瘤转移抑制基因蛋白（ｎｍ２３Ｈ１）的表达与食管鳞癌的临床病理特点及预后的关系，采用免疫组化ＳＰ法检测５５例食管鳞癌的ｎｍ２３Ｈ１的表达情况。结果显示５５例食管癌中，ｎｍ２３Ｈ１表达阳性率为５４．５％（３０／５５）。食管癌患者术后５ａ生存率与ｎｍ２３Ｈ１阳性表达率有明显正相关（Ｐ＜０．０５）。淋巴结转移者的ｎｍ２３Ｈ１阳性率（３８．９％）明显低于无淋巴结转移者（７５％，Ｐ＜０．０５）。患者性别、肿瘤大小、肿瘤分化程度及浸润深度与ｎｍ２３Ｈ１阳性表达率无关（Ｐ＜０．０５）。结果表明：ｎｍ２３Ｈ１可作为一种食管癌淋巴结转移及预后的重要生物学指标。
To investigate the relationship between the expression of tumor metastasis suppressor protein (nm23H1) and the clinicopathological features and prognosis of esophageal squamous cell carcinoma, immunohistochemical SP method was used to detect the expression of nm23H1 in 55 cases of esophageal squamous cell carcinoma. The results showed that in 55 cases of esophageal cancer, the positive rate of nm23-H1 expression was 54.5% (30/55). The 5-year survival rate of patients with esophageal cancer was positively correlated with the positive expression rate of nm23-H1 (P<0.05). The positive rate of nm23-H1 in lymph node metastasis (38.9%) was significantly lower than those without lymph node metastasis (75%, P<0.05). The gender, tumor size, tumor differentiation and depth of invasion were not associated with the positive rate of nm23-H1 expression (P<0.05). The results showed that: nm23-H1 can be used as an important biological indicator of lymph node metastasis and prognosis of esophageal cancer.