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羊水栓塞是一种少见而致命的分娩合并症。其主要的血液动力学改变为左心衰竭和肺动脉高压,其特征性变化为中心静脉压升高、全身血压下降及心排血量减少。临床上以在母血内找到羊水内容物而确诊。 内皮素-1是一种强有力的血管收缩剂,也具有收缩支气管的作用,在羊水中有很高的含量,目前认为是羊水栓塞的发病因素之一,但其致病机理尚未见报道。作者选用4个病例的肺组织进行对比研究,其中2例死于羊水栓塞(已经尸检证实),对照组的2例分别死于产前子痫所致的心跳骤停和脾动脉
Amniotic fluid embolism is a rare and fatal maternal complications. The main hemodynamic changes to left ventricular failure and pulmonary hypertension, the characteristic changes of central venous pressure, decreased systemic blood pressure and cardiac output decreased. Clinically to find the amniotic fluid content in maternal blood and confirmed. Endothelin-1 is a potent vasoconstrictor, also has the role of contracting bronchi, a high content in amniotic fluid, is currently considered one of the causes of amniotic fluid embolism, but its pathogenesis has not been reported. The authors selected four cases of lung tissue for comparative study, of which 2 died of amniotic fluid embolism (confirmed by autopsy), 2 cases of control group died of preeclampsia caused by cardiac arrest and splenic artery