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选择先天性心脏病小儿３５例，随机分为观察组（２０例）和吗啡组（１５例），观察组术前口服咪唑安定（０．５ｍｇ／ｋｇ）和氯胺酮（１２ｍｇ／ｋｇ）混合液，吗啡组肌肉注射吗啡（０．２ｍｇ／ｋｇ）。结果显示：观察组９０％的小儿易于与父母分离，与吗啡组（６６．７％）无明显差异（Ｐ＞０．０５）。达Ａ、Ｂ两级镇静者，观察组为８０％，吗啡组为４６．７％，两组差异非常显著（Ｐ＜０．０１）。观察组有８５％小儿静脉穿刺时合作或无反应，吗啡组仅４０％，两组差异显著（Ｐ＜０．０５）。两组麻醉诱导前和诱导时脉搏氧饱和度均正常，也未发生喉痉挛、缺氧、恶心和呕吐等井发症。术中血流动力学稳定，心脏自动复跳率、术后清醒时间、气管拔管时间和术后麻醉有关并发症，两组也无明显差异（Ｐ＞０．０５）。表明小儿心脏手术前口服咪唑安定和氯胺酮混合液，镇痛和镇静效果良好，血流动力学稳定，不增加围术期并发症，证明了术前口服咪唑安定和氯胺酮混合液在先天性心脏病小儿的安全性和可靠性。
Thirty-five children with congenital heart disease were randomly divided into observation group (20 cases) and morphine group (15 cases). The observation group was treated with midazolam (0.5 mg / kg) and ketamine (12 mg / Morphine group intramuscular injection of morphine (0.2mg / kg). The results showed that 90% of the children in the observation group were easily separated from their parents, which was not significantly different from that of the morphine group (66.7%) (P> 0.05). Up to A, B two sedation, the observation group was 80%, 46.7% morphine group, the difference between the two groups was significant (P <0.01). 85% of the observation group had venous puncture or non-response, morphine group only 40%, significant difference between the two groups (P <0.05). Both groups had normal pulse oximetry before induction and induction, and no laryngospasm, hypoxia, nausea and vomiting. Intraoperative hemodynamic stability, heart automatic rebound rate, postoperative wake-up time, tracheal extubation time and postoperative anesthesia-related complications, there was no significant difference between the two groups (P> 0.05). It shows that oral administration of midazolam and ketamine before cardiac surgery in children with good analgesic and sedation, hemodynamic stability, does not increase the perioperative complications, preoperative confirmed midazolam and ketamine mixed solution in congenital heart disease Pediatric safety and reliability.