论文部分内容阅读
黄酮类化合物是一类具有多种生理活性的天然有机化合物,广泛存在于自然界中,是许多植物药的有效成分。7-羟基黄酮化合物是众多黄酮化合物中的一种,它也具有广泛的生理活性,尤其是心血管活性,虽然作用较弱,但其副作用小,是个很好的合成7-羟基黄酮衍生物的反应底物。本论文采用改良的Baker-Venkatarama重排合成黄酮化合物的方法,实现了在碱性介质中使酯化反应和重排反应一步完成的合成黄酮化合物的路线。并以廉价易得的2,4-二羟基苯乙酮和苯甲酰氯为起始原料,经过酰化反应、酯化反应和重排反应,以重排反应为关键步骤,三步合成了7-羟基黄酮。然后通过IR对其进行验证。
Flavonoids are a class of natural organic compounds with a variety of physiological activities, are widely found in nature and are the active ingredients of many plant medicines. 7-Hydroxyflavone is one of many flavonoids, it also has a wide range of physiological activity, especially cardiovascular activity, although its effect is weak, but its side effect is small, it is a good synthetic 7-hydroxyflavone derivatives Reaction substrate. In this thesis, a modified Baker-Venkatarama rearrangement of synthetic flavonoids was used to achieve the route of synthesizing flavonoids with one-step esterification reaction and rearrangement reaction in alkaline medium. And cheap and readily available 2,4-dihydroxyacetophenone and benzoyl chloride as the starting material, after acylation, esterification and rearrangement reaction to the rearrangement reaction as the key step, three-step synthesis of 7 - Hydroxyflavone. It is then verified by IR.