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目的：探讨鼻咽癌（ＮＰＣ）ＶＥＧＦ表达与癌生物学行为的关系。方法：采用免疫组织化学ＳＰ法检测了６５例ＮＰＣ、１５例鼻咽良性肿瘤、１５例无瘤鼻咽部石蜡标本组织血管内皮细胞生长因子（ＶＥＧＦ）表达，鼻咽癌中转移组４１例，非转移组２４例。结果：ＮＰＣ组织ＶＥＧＦ表达显著高于鼻咽良性肿瘤组织中的表达，转移组又较非转移组的表达高，差异有显著性；ＶＥＧＦ表达与临床分期有关。结论：ＮＰＣ组织中ＶＥＧＦ表达与癌生物学行为密切相关，有可能作为判断肿瘤生物学行为、转移潜能及预后指标，有助于预测ＮＰＣ转移的高危患者，对采用血管生成抑制剂防止ＮＰＣ转移有参考价值。
Objective: To investigate the relationship between VEGF expression and biological behavior of nasopharyngeal carcinoma (NPC). Methods: Immunohistochemical SP method was used to detect the expression of vascular endothelial growth factor (VEGF) in 65 cases of NPC, 15 cases of benign nasopharyngeal tumors, 15 cases of non-tumorous nasopharyngeal paraffin specimens, 41 cases of metastasis in nasopharyngeal carcinoma, Non-metastasis group of 24 cases. Results: The expression of VEGF in NPC tissues was significantly higher than that in benign tissues of nasopharyngeal tissues. The expression of VEGF in NPC tissues was significantly higher than that in non-metastatic tumors. The expression of VEGF was correlated with clinical stage. CONCLUSIONS: The expression of VEGF in NPC is closely related to the biological behavior of NPC. It may serve as a prognostic indicator of tumor biological behavior, metastatic potential and prognosis, which may be useful for predicting the high-risk patients with NPC metastasis. It is suggested that the use of angiogenesis inhibitors to prevent NPC metastasis Reference value.