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目的为了探讨病毒之间的干扰现象，作者对慢性乙丙型病毒性肝炎重叠感染患者的血清肝炎病毒标志物的变化进行研究。方法１９９２年１月＿１９９４年１０月连续在我院住院确诊的慢性乙丙型病毒性肝炎重叠感染患者６０例，同期连续收住院的单纯慢性乙型肝炎患者１１０例作为对照组，比较两组患者入院时的血清乙型肝炎病毒标志物，并对观察组中２０例患者进行了随访，随访期０．５＿３年。结果入院时观察组ＨＢｅＡｇ和抗＿ＨＢｃＩｇＭ阳性率较对照组显著减少（１９／６０对５２／１０６，８／６０对２９／１１０，Ｐ＜０．０５），ＨＢｓＡｇ阴性率和抗＿ＨＢｅ阳性率显著增高（１０／／６０对５／１１０，Ｐ＜０．０１；３８／６０对４８／１０６，Ｐ＜０．０５）。观察组２０例随访发现，ＨＢＶ＿ＤＮＡ阳性及ＨＢＶ＿ＤＮＡ，ＨＣＶ＿ＲＮＡ二项同时阳性例数都比入院时明显减少（４／２０对１０／２０，Ｐ＜０．０５；１／２０对７／２０，Ｐ＜０．０５）。结论慢性乙丙型病毒性肝炎重叠感染时存在病毒干扰现象
Objective To investigate the interference between viruses, the authors studied the changes of serum hepatitis virus markers in patients with overlapping hepatitis B virus infection. Methods From January 1992 to October 1994, 60 consecutive patients with chronic hepatitis B virus infection who were hospitalized in our hospital were consecutively admitted, and 110 patients with chronic hepatitis B who were hospitalized in the same period were selected as the control group. Patients in both groups Serum hepatitis B virus markers at admission, and 20 patients in the observation group were followed up for 0.5-3 years. Results The positive rates of HBeAg and anti-HBcIgM in the observation group were significantly lower than those in the control group (19/60 vs. 52/106, 8/60 vs. 29/110, P <0.05), and the positive rates of HBsAg and anti-HBe were significantly higher (10 // 60 vs 5/110, P <0.01; 38/60 vs 48/106, P <0.05). The follow-up of 20 cases in the observation group showed that the positive cases of HBV DNA and the positive cases of both HBV DNA and HCV RNA were significantly lower than those on admission (4/20 vs. 10/20, P <0.05; 1/20 vs. 7/20, P < 0.05). Conclusion There is virus interference in the overlap infection of chronic hepatitis B virus