爱狄森氏病(Addison’s disease)通常由自身免疫性肾上腺炎引起,如果诊断治疗正确,其预后良好。事实上,仅急性肾上腺危象与死亡相关。爱狄森危象常由其他疾病诱发,并且与持续性呕吐有关,呕吐影响胃肠吸收氢化可的松(HC),这时需肌肉注射。如果直肠内施用能成功达到自我处理的目的,就避免了多次注射。本文研究HC栓剂的直肠吸收,并与常规肌注HC达到的血浆浓度作了 Addison’s disease is usually caused by autoimmune adrenitis and has a good prognosis if the diagnosis is correct. In fact, only acute adrenal crisis is associated with death. Edison crisis is often caused by other diseases, and is associated with persistent vomiting, vomiting affects gastrointestinal absorption of hydrocortisone (HC), when the need for intramuscular injection. Multiple injections are avoided if intrarectal administration successfully achieves the goal of self-treatment. This article investigates the rectal absorption of HC suppositories and compares them to the plasma concentrations achieved with conventional intramuscular HC