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目的:探究磷酸肌酸钠配合大剂量维生素C对小儿肺炎支原体感染心肌损害患儿炎症因子的影响。方法:收集我院收治的肺炎支原体感染心肌损害患儿72例,根据治疗方法不同分为对照组和试验组,每组36例。对照组给予磷酸肌酸钠治疗,试验组给予磷酸肌酸钠联合维生素C治疗。观察并比较两组患儿治疗前后心肌酶、心功能、炎症因子水平、临床疗效及不良反应。结果:与治疗前比较,治疗后两组患儿血清心肌酶水平均降低,且试验组低于对照组,差异均具有统计学意义(P<0.05)。与治疗前比较,治疗后两组患儿心排出量、每搏输出量均升高,且试验组高于对照组,差异均具有统计学意义(P<0.05);与治疗前比较,治疗后两组患儿血清IL-18,IL-6及IL-17水平均降低,且试验组低于对照组,差异均具有统计学意义(P<0.05);与治疗前比较,治疗后两组患儿血清TGF-β水平均升高,且试验组高于对照组,差异均具有统计学意义(P<0.05)。试验组临床总有效率(91.67%)高于对照组(72.22%),差异具有统计学意义(P<0.05)。结论:磷酸肌酸钠配合大剂量维生素C治疗小儿肺炎支原体感染心肌损害的临床疗效显著,能够改善心肌功能,抑制炎性反应,安全性较高。
Objective: To investigate the effects of sodium creatine phosphate combined with high-dose vitamin C on inflammatory cytokines in children with Mycoplasma pneumoniae Myocardial Injury. Methods: Seventy-two children with Myocarditis Mycoplasma infection in our hospital were divided into control group and experimental group according to different treatment methods, with 36 cases in each group. The control group was treated with sodium creatine phosphate, and the experimental group was treated with sodium creatine phosphate combined with vitamin C. The levels of myocardial enzymes, cardiac function, inflammatory cytokines, clinical efficacy and adverse reactions in both groups before and after treatment were observed and compared. Results: Compared with those before treatment, the levels of serum myocardial enzymes decreased in both groups after treatment, and the levels in the experimental group were lower than those in the control group. The differences were statistically significant (P <0.05). Compared with those before treatment, the cardiac output and stroke output in both groups increased after treatment, and the experimental group was higher than the control group (P <0.05). Compared with before treatment, after treatment The serum levels of IL-18, IL-6 and IL-17 in both groups were decreased, and the experimental group was lower than the control group, the difference was statistically significant (P <0.05); compared with before treatment, Serum TGF-β levels were elevated, and the experimental group was higher than the control group, the difference was statistically significant (P <0.05). The total effective rate of the experimental group (91.67%) was higher than that of the control group (72.22%), the difference was statistically significant (P <0.05). Conclusion: Sodium creatine phosphate combined with high-dose vitamin C treatment of children with Mycoplasma pneumoniae infection of myocardial damage significant clinical effect, can improve myocardial function, inhibit inflammatory response, high safety.