Objective This study aims to investigate the protection of procyanidins and lycopene from the renal damage induced by mercuric chloride.Methods Rats were treated with either procyanidins or lycopene 2h before HgCl 2 subcutaneously injection,once daily treatment for 2 successive days.Results In comparison with HgCl 2 group,markers of renal function such as blood urea nitrogen in serum and urinary protein were decreased to (18.45±11.63) mmol/L and (15.93±9.36) mmol/L,(4.54±0.78) g/(g Cr) and (4.40±1.12) g/(g Cr).N‐acetyl‐beta‐D‐glucosaminidase,lactate dehydrogenase,alkaline phosphatase in urine were depressed to (125.49±11.68) U/(g Cr),(103.73±21.79) U/(g Cr),(101.99±12.28) U/(g Cr),and (113.19±23.74) U/(g Cr),(71.14±21.80) U/(g Cr),(73.64±21.51) U/(g Cr) in procyanidins and lycopene groups.Indicators of oxidative stress,for example,Glutathion was reduced to (45.58±9.89) μmol/(g pro) and (45.33±5.90) μmol/(g pro),and antioxidant enzymes such as superoxide dismutase,glutathione‐peroxidase were enhanced to (43.07±10.97) U/(mg pro) and (39.94±6.04) U/(mg pro),(83.85±18.48) U/(mg pro),and (85.62±12.68) U/(mg pro).Malondialdehyde was lowered to (0.95±0.12) (μmol/g pro) and (1.03±0.12) μmol/(g pro) in procyanidins and lycopene groups.ROS generation was decreased by 27.63% and 16.40% and apoptosis was also decreased in procyanidins and lycopene groups respectively.Pathological changes were much better as well.Conclusion Procyanidins and Lycopene play some protective role against mercury kidney damage. Objective This investigate aims to investigate the protection of procyanidins and lycopene from the renal damage induced by mercuric chloride. Methods Rats were treated with either procyanidins or lycopene 2h before HgCl 2 subcutaneously injected, once daily treatment for 2 successive days. Results In comparison with HgCl 2 group, markers of renal function such as blood urea nitrogen in serum and urinary protein were decreased to (18.45 ± 11.63) mmol / L and (15.93 ± 9.36) mmol / L, (4.54 ± 0.78) g / (g Cr) and (4.40 ± 1.12) g / (g Cr) .N-acetyl-beta-D-glucosaminidase, lactate dehydrogenase, alkaline phosphatase in urine were depressed to (125.49 ± 11.68) U / (g Cr), (103.73 ± 21.79) U / (g Cr), (101.99 ± 12.28) U / (g Cr), and (113.19 ± 23.74) U / (g Cr), (71.14 ± 21.80) U / (g Cr), (73.64 ± 21.51) U / (g Cr) in procyanidins and lycopene groups. Indicators of oxidative stress, for example, Glutathion was reduced to (45.58 ± 9.89) μmol / (g pro) and (45.33 ± 5.90) ​​μmol / (g pro) as superoxide dismutase, (43.07 ± 10.97) U / (mg pro) and (39.94 ± 6.04) U / (mg pro), 83.85 ± 18.48 U / mg pro and 85.62 ± 12.68 U / (mg pro) .Malondialdehyde was lowered to (0.95 ± 0.12) (μmol / g pro) and (1.03 ± 0.12) μmol / (g pro) in procyanidins and lycopene groups. ROS generation was decreased by 27.63% and 16.40% and apoptosis was also decreased in procyanidins and lycopene groups respectively. Pathological changes were much better as well. Conclusions Procyanidins and Lycopene play some protective role against mercury kidney damage.