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目的:研究OSAHS与冠状动脉病变程度及预后的关系。方法:将OSAHS患者根据睡眠呼吸监测结果分为轻度、中度和重度组,通过计数病变累及冠状动脉数、计算Gensini评分及评价TIMI血流分级比较各组冠状动脉病变严重程度;2年内对患者进行随访,比较各组间临床心脏主要不良事件发生情况。结果:经冠状动脉造影检查证实,3组患者随OSAHS病变程度加重,冠状动脉血管病变支数所占比例有所增加,TIMI血流分级降低,Gensin评分增高,差异有统计学意义(P<0.05)。3组患者在药物服用依从性方面差异无统计学意义(P>0.05);3组患者两年内的临床心脏主要不良事件(MACE)发生率分别为16.28%、29.36%以及44.26%。随OSAHS病变程度加重,临床心脏主要不良事件发生率增加,差异有统计学意义(P<0.05)。结论:随OSAHS病变程度加重,OSAHS患者冠状动脉病变严重程度加重,并且会增加患者预后的临床心脏主要不良事件发生率,其发生率随OSAHS病变程度加重而增加。
Objective: To study the relationship between OSAHS and coronary artery disease and prognosis. Methods: The OSAHS patients were divided into mild, moderate and severe groups according to the results of sleep-respiration monitoring. The severity of coronary artery lesions in each group was compared by counting the number of coronary arteries involved in the lesion, calculating the Gensini score and evaluating the TIMI grade. Patients were followed up to compare the incidence of major adverse cardiac events in each group. Results: Coronary angiography confirmed that the severity of OSAHS increased with the severity of OSAHS and the proportion of coronary artery lesion in TIMP-1 and TIMP-1, TIMI grade decreased and Gensin score increased (P <0.05) ). There was no significant difference in medication compliance between the three groups (P> 0.05). The incidences of MACE in three groups were 16.28%, 29.36% and 44.26% respectively within two years. With the severity of OSAHS increased, the incidence of clinical cardiac adverse events increased, the difference was statistically significant (P <0.05). CONCLUSIONS: With the increasing severity of OSAHS, the severity of coronary lesions in OSAHS patients increases, and the incidence of clinical adverse cardiac events in patients with OSAHS increases. The incidence of OSAHS increases with the severity of OSAHS.