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作者对20名药物未能有效控制的各型顽固性癫痫病人进行了丙戊酸钠(VPA)的药物动力学及毒性研究.20名病人中,10名为成人,10名为儿童,除1例外都正在服用多种抗癫痫药物.成人癫痫病期达7-37年,儿童达2-10年.成人癫痫类型为失神及全身强直—阵挛发作3例、单纯失神发作1例、复杂部份性及失神发作1例、复杂部份性发作5例;儿童为失神发作1例、失神及全身强直—阵挛发作2例、非典型失神、全身强直—阵挛及无张力性混合发作4例、家族性进行性肌阵挛癫痫1例、继发性全身性部份发作1例、复杂性部份性伴无张力性发作1例、每位病人除进行一般检查,化验,血浆抗癫痫药物浓度测定外;并记录脑电图变化及测定VPA的高峰血浆浓度与半衰期.上述项目进行完毕
The authors studied the pharmacokinetics and toxicity of sodium valproate (VPA) in 20 patients with various types of intractable epilepsy that did not effectively control the drug.2 Of the 20 patients, 10 were adults and 10 were children, except 1 Exceptions are taking a variety of anti-epileptic drugs .In the adult epilepsy period of 7 to 37 years, children for 2 to 10 years .Activities of the type of adult epilepsy and generalized tonic - clonic seizures in 3 cases, simple absence of the attack in 1 case, complex 1 case of partial and absence seizures, 5 cases of complex partial seizures; 1 case of absence seizure in children, 2 cases of absence and generalized tonic-clonic seizures, atypical absence absence, generalized tonic-clonic and non-tonic mixed seizures 4 For example, 1 case of familial progressive myoclonic epilepsy, 1 case of secondary generalized seizures, and 1 case of complex sexual partners without tension. In addition to general examination, laboratory tests, plasma anti-epilepsy Drug concentration was measured; and EEG changes were recorded and measured peak plasma VPA concentration and half-life of the above project was completed