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为探讨硫酸镁（ＭＳ）不同剂量与速度静注对家兔心率（ＨＲ）、平均动脉压（ＭＡＰ）和心脏复跳的影响。分别用ＭＳ以０．１、１、３０、６０ｍｇ／ｋｇ·ｍｉｎ的速度静注１０只家兔，各维持１５ｍｉｎ，观察其ＨＲ和ＭＡＰ变化，再以１２０ｍｇ／ｋｇ·ｍｉｎ的速度静注到家兔心脏停搏，停搏后立即停注，同时行心脏按摩和静注异丙肾上腺素０．５ｍｇ／ｋｇ，２ｍｉｎ后再静注新福林１ｍｇ／ｋｇ。结果：０．１、１ｍｇ／ｋｇ·ｍｉｎ的静注速度对ＨＲ、ＭＡＰ无减慢和降低作用（Ｐ＞０．０５）。而以３０、６０ｍｇ／ｋｇ·ｍｉｎ的速度静注，ＨＲ、ＭＡＰ都明显减慢和降低（Ｐ＜０．０５）；速度为１２０ｍｇ／ｋｇ·ｍｉｎ时ＨＲ和ＭＡＰ都很快减慢和降低，心脏在５～３７ｍｉｎ内不经过任何室速或室颤下停搏，经停注ＭＳ、按摩和静注异丙肾上腺素等措施，１０只家兔都在１～２ｍｉｎ内恢复心跳和一定的ＭＡＰ。结果表明，快速静注ＭＳ能有效地减慢ＨＲ和降低心肌收缩力，对心肌有一定保护性和可逆性，为ＭＳ在临床麻醉的应用提供参考。
To investigate the effects of different doses and speeds of magnesium sulfate (MS) on heart rate (HR), mean arterial pressure (MAP) and heart reentry in rabbits. Ten rabbits were intravenously injected with MS at the rates of 0.1, 1, 30, and 60 mg / kg · min respectively for 15 min and observed for changes in HR and MAP. The rabbits were intravenously injected with 120 mg / kg · min Rabbit cardiac arrest, stop immediately after stopping, while cardiac massage and intravenous isoproterenol 0.5mg / kg, 2min and then intravenous injection of new Forint 1mg / kg. Results: 0.1, 1mg / kg · min intravenous injection of HR, MAP did not slow down and reduce the role (P> 0.05). However, HR and MAP both slowed down and decreased significantly at 30, 60mg / kg · min (P <0.05). At 120mg / kg · min, HR and MAP both slowed down and decreased rapidly, Heart in 5 ~ 37min without any ventricular tachycardia or ventricular fibrillation under arrest, stop the injection of MS, massage and intravenous isoproterenol and other measures, 10 rabbits in 1 ~ 2min to recover the heartbeat and MAP . The results showed that rapid intravenous injection of MS can effectively slow down the HR and reduce myocardial contractility, myocardial protective and reversible, and provide a reference for the application of MS in clinical anesthesia.