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目的回顾性分析脑胶质瘤患者术后放射治疗的疗效,探讨评价影响放射治疗胶质瘤预后的因素。方法对临床资料完整的112例脑胶质瘤患者进行回顾性分析,其中Ⅰ～Ⅱ级胶质瘤54例,Ⅲ～Ⅳ级58例。手术全切61例,次全切43例,单纯活检8例。术后等待放射治疗的中位时间为27.5 d,放射治疗的中位剂量为56 Gy。采用Cox比例风险模型进行预后的单因素和多因素分析。结果低分级胶质瘤的1,3年生存率分别为88.9%和53.0%;高分级胶质瘤的1,3年生存率分别为68.9%和17.2%。年龄≤40岁、低分级胶质瘤、手术全切肿瘤、放疗前Karnofsky评分≥80分的患者预后较好。结论年龄、病理分级、手术切除程度以及放疗前的功能状况是影响胶质瘤放射治疗预后的独立因素。
Objective To retrospectively analyze the curative effect of postoperative radiotherapy in patients with glioma and to evaluate the factors influencing the prognosis of radiotherapy glioma. Methods The clinical data of 112 patients with glioma were retrospectively analyzed, of which 54 were grade Ⅰ ~ Ⅱ glioma and 58 were grade Ⅲ ~ Ⅳ. Surgical removal of 61 cases, subtotal 43 cases, simple biopsy in 8 cases. The median time for postoperative radiotherapy was 27.5 days and the median dose for radiotherapy was 56 Gy. Univariate and multivariate analyzes using Cox proportional hazard model for prognosis. Results The 1-year and 3-year survival rates of low-grade gliomas were 88.9% and 53.0%, respectively. The 1-year and 3-year survival rates of high-grade gliomas were 68.9% and 17.2%, respectively. Age ≤ 40 years old, low-grade gliomas, surgical total resection of the tumor, Karnofsky score ≥ 80 points before radiotherapy in patients with good prognosis. Conclusion Age, pathological grade, degree of surgical resection and the functional status before radiotherapy are the independent factors affecting the prognosis of glioma radiotherapy.