目的探讨肝脏局灶性结节性增生(FNH)的临床诊断特点及治疗选择。方法回顾性分析28例经手术后病理证实为FNH患者的临床资料。结果在28例患者中,20例(71.4%)无明显症状,24例(85.7%)肝功能正常,3例(10.7%)HBsAg阳性,甲胎蛋白及癌胚抗原检查均正常。超声检查20个(75.0%)病灶为低回声,超声造影3个(75%)病灶为快进慢出。多数病灶CT和MRI检查有特征性表现。治疗采用肝脏不规则切除术,24例定期随访3个月至6年。患者术后疗效确切,未见肿瘤复发,包括术后病理显示存在不典型增生的4个病灶。结论FNH无特异性的临床表现;影像检查对其有较高的诊断价值;对有治疗指征者,手术切除是较好的选择。 Objective To investigate the clinical features and treatment options of focal nodular hyperplasia (FNH) in the liver. Methods The clinical data of 28 patients with pathologically confirmed FNH were retrospectively analyzed. Results Of the 28 patients, 20 (71.4%) had no obvious symptoms, 24 (85.7%) had normal liver function, 3 (10.7%) had HBsAg positive, and both alpha-fetoprotein and carcinoembryonic antigen were normal. Echocardiography 20 (75.0%) lesions were hypoechoic, and 3 (75%) of CEUS lesions were fast-forward and slow-out. CT and MRI examination of most lesions have characteristic performance. Treatment of hepatic irregular hepatectomy, 24 cases were followed up for 3 months to 6 years. The patient’s curative effect is exact, no recurrence of tumor, including 4 lesions with atypical hyperplasia after pathological examination. Conclusion FNH has no specific clinical manifestations; imaging examination has high diagnostic value; for those who have indications for treatment, surgical resection is a better choice.