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目的探讨含左氧氟沙星三联疗法治疗幽门螺旋杆菌(HP)的疗效及安全性。方法128例HP阳性的慢性胃炎伴有消化不良症状患者随机分为治疗组和对照组,每组各64例。治疗组给予兰索拉唑、阿莫西林、左氧氟沙星治疗,对照组给予兰索拉唑、阿莫西林、甲硝唑治疗,疗程均为一周,停药四周后复查Hp阴性者为根除,阳性者为未根除。结果含左氧氟沙星疗法的治疗组64例患者中完全转阴者54例,占84.4%,仍为阳性者10例,占15.6%,对照组64例患者中完全转阴者42例,占65.6%,仍为阳性者22例,占34.4%。不良反应治疗组出现恶心呕吐3例,皮疹、皮肤瘙痒1例。对照组出现恶心呕吐4例,食纳下降2例,口腔烧灼金属味1例,腹泻2例。结论含左氧氟沙星方案根除Hp效果更显著,根除率高,不良反应少,值得临床推广。
Objective To investigate the efficacy and safety of levofloxacin triple therapy in the treatment of Helicobacter pylori (HP). Methods 128 cases of HP-positive chronic gastritis with dyspeptic symptoms were randomly divided into treatment group and control group, 64 cases in each group. Patients in the treatment group were given lansoprazole, amoxicillin and levofloxacin. The patients in the control group were treated with lansoprazole, amoxicillin and metronidazole. The course of treatment was one week. Hp-negative patients were re-examined after four weeks of withdrawal Not eradication. Results Of the 64 patients treated with levofloxacin therapy, 54 patients (84.4%) were completely negative and 10 (15.6%) were still positive, while 42 patients (65.6%) were completely negative in 64 patients in the control group, 22 were still positive, accounting for 34.4%. Adverse reactions in treatment group nausea and vomiting in 3 cases, skin rash, skin itching in 1 case. The control group showed nausea and vomiting in 4 cases, decreased appetite in 2 cases, oral burning metal taste in 1 case and diarrhea in 2 cases. Conclusions The levofloxacin-containing regimen is more effective in eradicating Hp, with a high eradication rate and less adverse reactions, which is worthy of clinical promotion.