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目的:研究三七总皂甙对急性甲胺磷农药中毒肾脏损伤的保护作用。方法:健康日本大耳兔24只,随机分为3组,每组8只。急性甲胺磷农药中毒组,胃管灌入甲胺磷油剂4 mg/kg;三七总皂甙保护组在灌入甲胺磷前30 min 静脉滴注三七总皂甙100 mg/kg;正常对照组与急性甲胺磷农药中毒组同时静脉滴注等量的0.9%氯化钠液。观察3组动物血清尿素氮(BUN)、肌酐(Cr)、胆碱酯酶(CHE)、肿瘤坏死因子(TNF)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)在0、4、8 h 的变化值;同时观察8 h 后肾脏病理学变化。结果:甲胺磷农药中毒组 BUN、Cr、TNF、IL-6、IL-8较对照组、三七总皂甙保护组升高,差异有显著性(P<0.01);CHE 较对照组降低(P<0.01),与三七总皂甙保护组相似(P>0.05);病理学检查示甲胺磷农药中毒组肾组织损伤明显大于三七总皂甙保护组。结论:三七总皂甙对急性甲胺磷中毒致肾脏损伤具有保护作用。
Objective: To study the protective effect of panax notoginseng saponins on acute renal injury induced by methamidophos pesticide poisoning. Methods: Twenty-four healthy Japanese rabbits were randomly divided into 3 groups with 8 in each group. In the acute methamidophos poisoning group, the gastric tube was infused with methamidophos 4 mg/kg; the total panax notoginseng protected group was intravenously infused with panax notoginseng saponin 100 mg/kg 30 minutes before the infusion of methamidophos; In the control group and the acute methamidophos poisoning group, an equal amount of 0.9% sodium chloride solution was intravenously infused. Observe the blood urea nitrogen (BUN), creatinine (Cr), cholinesterase (CHE), tumor necrosis factor (TNF), interleukin-6 (IL-6), interleukin-8 (IL- 8) Change values at 0, 4, and 8 h; simultaneous observation of renal pathological changes after 8 h. Results: The levels of BUN, Cr, TNF, IL-6 and IL-8 in the methamidophos poisoning group were higher than those in the control group and the Panax notoginseng saponin protection group (P<0.01). CHE was lower than the control group ( P<0.01), similar to the Panax notoginseng saponin protection group (P>0.05); pathological examination showed that the renal tissue damage in the methamidophos poisoning group was significantly greater than the Panax notoginseng saponin protection group. Conclusion: Panax notoginseng saponins has protective effect on renal damage caused by acute methamidophos poisoning.