论文部分内容阅读
目的观察阿霉素毫微粒（ＮＡＤＭ）经动脉给药对大鼠肝肿瘤的疗效。方法以界面聚合法制备ＮＡＤＭ，建立大鼠移植性Ｗ２５６肝癌模型并随机分为四组，经肝动脉分别注入生理盐水、游离阿霉素（ＡＤＭ，２ｍｇ／ｋｇ）、游离阿霉素加空白毫微粒（ＡＤＭ＋ＮＰ，２ｍｇ／ｋｇ）与ＮＡＤＭ（２ｍｇ／ｋｇ）。结果经ＮＡＤＭ治疗的大鼠生存期显著延长（Ｐ＜０．０１），与ＡＤＭ及ＡＤＭ＋ＮＰ组相比对肿瘤生长的抑制更为明显（Ｐ＜０．０１），肿瘤坏死更广泛，更彻底。结论ＮＡＤＭ经动脉给药疗效肯定，且优于ＡＤＭ水溶液
Objective To observe the effect of arterial administration of adriamycin nanoparticles (NADM) on liver tumors in rats. METHODS: NADM was prepared by interfacial polymerization. Rat model of transplanted W256 liver cancer was established and randomly divided into four groups. Injected with saline, free adriamycin (ADM, 2 mg/kg), free doxorubicin plus blank Microparticles (ADM+NP, 2 mg/kg) and NADM (2 mg/kg). Results The survival time of NADM-treated rats was significantly prolonged (P<0.01). Compared with ADM and ADM+NP groups, tumor growth was more significantly inhibited (P<0.01). Tumor necrosis was more extensive and more complete. Conclusion The curative effect of NADM in arterial administration is positive and superior to ADM solution