Objective: The aim of this study was to study the expression and the clinical pathological relationship of p27 and Skp2 in the tissues of colorectal cancer,discuss the correlation between them.Methods: To determine the expressions of p27and Skp2 among 30 cases of colorectal cancer tissue specimen and 18 cases of normal colorectal tissue samples with immunohistochemistry SP method.Results: The average positive rate of p27 among the normal colorectal tissue samples was55.2%,which was obviously higher than that of colorectal cancer tissue samples(27.5%,P