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抗凝血酶Ⅱ(AT-Ⅲ)灭活除胰舒血管素及血浆素之外的凝血因子如 X_a、Ⅸ_a及Ⅺ_a因子,形成复合物,这些复合物的发现表明凝血因子生理性或病理性的激活。Sas 等发现在第一相中,将肝素加入琼脂糖凝胶,可得到免疫抗凝血酶Ⅱ(IAT-Ⅱ)的三个分离的沉淀峰,如果 AT-Ⅱ上的结合位置,全部或部分地被活化的凝血因子占据,则兔疫沉淀图发生变化,表现为 IAT-Ⅱ:及 IAT-Ⅲ_3增加,同时有主要分子部分 IAT-Ⅲ_1的减低。作者用改进的IAT-Ⅲ电泳法,测定了正常人及5例急性白血病DIC 时 IAT-Ⅲ电泳图象变化。患者均进行了常规DIC 检查。
Antithrombin Ⅱ (AT-Ⅲ) inactivates coagulation factors such as X_a, IX_a and XI_a factors other than pancreatic vasopressin and plasma factor to form complexes, and the discovery of these complexes indicates that the coagulation factors are physiologically or pathologically Activation. Sas et al. Found that in the first phase, the addition of heparin to the agarose gel yielded three separate precipitation peaks of the immune antithrombin II (IAT-II). If the binding site on AT-II, all or part of The activation of coagulation factors, the rabbit epidemic precipitation map changes, the performance of IAT-Ⅱ: and IAT-Ⅲ_3 increased, while the main part of the molecular IAT-Ⅲ_1 reduction. The authors used improved IAT-III electrophoresis to determine the change of IAT-III electrophoresis image of normal people and 5 cases of acute leukemia DIC. All patients underwent routine DIC examinations.