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８名健康志愿者口服单剂量０．６ｇ甲硝唑，次日开始连服６ｄ西咪替丁０．４ｇ，ｂｉｄ，第７ｄ再次口服同量甲硝唑。以高效液相色谱（ＨＰＬＣ）法测定收集的甲硝唑唾液浓度，用３Ｐ８７软件计算药动学参数。结果表明，单用甲硝唑组与西咪替丁＋甲硝唑组药－时曲线均符合一室模型。合用组的消除半衰期（Ｔ１／２Ｋｅ＝３．１ｈ）；较单用组（７．０ｈ）为短，差异非常显著（Ｐ＜０．０１）。合用组的ＡＵＣ（６５ｍｇ·ｈ·Ｌ－１）也较单用组（１１８ｍｇ·ｈ·Ｌ－１）为小，差异显著（Ｐ＜０．０５）。Ｃｍａｘ两组接近。
Eight healthy volunteers oral single dose of 0.6g metronidazole, the next day even with cicilbine 6d 0.4g, bid, 7d again the same amount of oral metronidazole. The concentrations of metronidazole saliva collected were determined by high performance liquid chromatography (HPLC) and the pharmacokinetic parameters were calculated by 3P87 software. The results showed that the single-metronidazole group and cimetidine + metronidazole group-time curve are in line with the one-compartment model. The elimination half-life (T1 / 2Ke = 3.1h) in the combined group was shorter than that in the single-use group (7.0h) and the difference was significant (P <0.01). The AUC (65mg · h · L-1) in the combined group was also smaller than that in the single-use group (118mg · h · L-1), with significant difference (P <0.05). Cmax two groups close.