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目的探讨血清中部分常量元素水平在肺癌患者中的检测价值。方法回顾性分析鄞州人民医院2012年1月1日—2013年10月30日259例病例资料,按临床诊断分为4组:腺癌组68位(占26.3%)、鳞癌组63位(占24.3%)、肺部感染组68位(占26.2%)及常规体检组60位(占23.2%),分别收集每位病例的血清无机磷、血清钙及血清镁水平数值。通过SPSS 19.0统计软件包统计分析其在肺癌中的价值。结果 4组病例中,性别、吸烟史及病例分组等一般资料无显著性差异。血清无机磷水平(单位:mmol/L):腺癌组(1.10±0.19)和鳞癌组(1.02±0.16)、腺癌(1.10±0.19)和常规体检组(1.19±0.20),差异有统计学意义(P<0.05);鳞癌组(1.02±0.16)和肺炎组(1.13±0.17)、鳞癌组(1.02±0.16)和常规体检组(1.19±0.20),差异有统计学意义(P<0.01);肺炎组(1.02±0.16)和常规体检组(1.19±0.20)、腺癌组(1.10±0.19)和肺炎组(1.13±0.17),差异均无统计学意义(P>0.05)。血总钙浓度和血镁浓度在不同病例组中差别无统计学意义(P>0.05)。ⅠA期肺癌与ⅡB期肺癌患者中血磷浓度比较差异有统计学意义(1.13±0.17)mmol/L vs(0.96±0.14)mmol/L(P=0.029),余各分期间血磷浓度差异无统计学意义(P>0.05);不同分期间血钙及血镁浓度差异均无统计学意义(P>0.05)。腺癌组男女性别中血磷浓度差异有统计学意义(1.01±0.20)mmol/L vs(1.12±0.10)mmol/L(P=0.026),余各分组间男女性别中血鳞浓度差异无统计学意义(P>0.05);不同分组间血钙及血镁浓度在男女性别中差异均无统计学意义(P>0.05)。结论血清无机磷水平在肺癌患者和非肺癌患者及健康病例中差别明显,血清钙及血清镁水平在肺癌患者及其他病例组中差别无显著性意义;血清磷水平可作为临床判断肺癌的一个辅助参考指标,但其临界值及其参考价值有多大有待进一步研究。
Objective To investigate the detection value of some constant element levels in serum in patients with lung cancer. Methods The data of 259 cases in Yinzhou People’s Hospital from January 1, 2012 to October 30, 2013 were retrospectively analyzed. According to clinical diagnosis, they were divided into 4 groups: 68 in adenocarcinoma (26.3%), 63 in squamous cell carcinoma Accounting for 24.3%), 68 (26.2%) patients in the lung infection group and 60 (23.2%) patients in the routine examination group. The levels of serum inorganic phosphorus, serum calcium and serum magnesium were collected for each case. Through SPSS 19.0 statistical package statistical analysis of its value in lung cancer. Results There were no significant differences in the general data of gender, smoking history and case group among the 4 groups. The levels of serum inorganic phosphorus (mmol / L) in adenocarcinoma group (1.10 ± 0.19) and squamous cell carcinoma group (1.02 ± 0.16), adenocarcinoma (1.10 ± 0.19) and routine physical examination group (1.19 ± 0.20) (P <0.05). There were significant differences between the squamous cell carcinoma group (1.02 ± 0.16) and the pneumonia group (1.13 ± 0.17), the squamous cell carcinoma group (1.02 ± 0.16) and the conventional physical examination group (1.19 ± 0.20) (P <0.05). There was no significant difference between the pneumonia group (1.02 ± 0.16) and the routine examination group (1.19 ± 0.20), adenocarcinoma group (1.10 ± 0.19) and pneumonia group (1.13 ± 0.17) Blood total calcium concentration and blood magnesium concentration in different cases were no significant difference (P> 0.05). There were significant differences in serum phosphorus levels between stage ⅠA and stage ⅡB lung cancer patients (1.13 ± 0.17) mmol / L vs (0.96 ± 0.14) mmol / L (P = 0.029) Statistical significance (P> 0.05). There was no significant difference in serum calcium and magnesium between different periods (P> 0.05). There were significant differences in serum phosphorus levels between male and female patients with adenocarcinoma (1.01 ± 0.20) mmol / L vs (1.12 ± 0.10) mmol / L (P = 0.026) (P> 0.05). There was no significant difference in serum Ca2 + and Mg2 + between different groups (P> 0.05). Conclusions The level of serum inorganic phosphorus in lung cancer patients and non-lung cancer patients and healthy patients were significantly different. Serum calcium and serum magnesium levels were not significantly different between lung cancer patients and other cases. Serum phosphorus level could be used as a clinical assistant in diagnosing lung cancer Reference index, but its critical value and its reference value how much remains to be further studied.