用充液球囊拉伤动脉内膜、高胆固醇饲养和狭窄部位血管成形术的方法建立了兔右颈动脉再狭窄模型。在观察形态学变化的同时，用放射免疫方法测定了手术前后不同时间的狭窄局部动脉组织中前列环素代谢产物６－酮－前列腺素Ｆ－１α（６－ｋｅｔｏ－ＰＧＦ，１α）含量。结果发现，再狭窄模型动脉手术后１天～４周该项指标均明显低于术前的测位（Ｐ＜０．０１），提示局部组织前列环素含量下降与再狭窄形成有关 A rabbit model of right carotid artery restenosis was established by means of balloon-inflated balloon catheter, arterial intimal hypercholesterolemia, and angioplasty of stenosis. Simultaneously with morphological changes, the content of 6-keto-PGF (1α), a metabolite of prostacyclin, in stenotic local arterial tissue was measured by radioimmunoassay at different time points before and after surgery. The results showed that restenosis model arterial surgery 1 day to 4 weeks after the index were significantly lower than the preoperative positioning (P <0.01), suggesting that local tissue prostacyclin content decreased with the formation of restenosis