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目的目前有大量研究发现乳腺癌化疗后的记忆障碍存在异质性,是否与分子分型有关目前尚不明确。本研究试图了解三阴性乳腺癌(triple-negative breast cancer,TNBC)和非三阴性乳腺癌(non-triple-negative breast cancer,NTNBC)化疗后的记忆障碍是否存在差异,以及TNBC化疗后的回顾性记忆(retrospective memory,RM)与前瞻性记忆(prospective memory,PM)损害特征。方法以安徽医科大学第二附属医院肿瘤科2014-03-01-2015-06-30的TNBC和NTNBC术后辅助化疗后患者各30例为观察组,同时将年龄、教育程度及体能状况等与观察组相匹配的60名健康女性志愿者为对照组,分别对其进行简易精神状态量表(mini-mental state examination,MMSE)测查及RM和PM问卷调查。结果与健康对照组对比,观察组的MMSE、RM和PM得分分别为(27.08±1.37)、(17.97±4.34)和(18.78±4.24)分,差异均有统计学意义,t值分别为2.880、-6.486和-8.645,均P<0.05;与NTNBC组对比,TNBC组MMSE、RM和PM得分分别为(26.50±1.67)、(19.30±2.60)和(20.33±3.50)分,差异均有统计学意义,t值分别为3.624、-2.483和-3.018,均P<0.05。结论乳腺癌化疗后患者存在不同程度的RM障碍和PM障碍,且TNBC患者的RM和PM损害均较NTNBC患者显著,提示激素受体的不同表达可能与乳腺癌化疗后记忆障碍发生的异质性有关。
Objective There are a large number of studies found that there is heterogeneity of memory dysfunction after chemotherapy in breast cancer and whether it is related to molecular typing is not yet clear. This study sought to determine if there is any difference in memory impairment after triple-negative breast cancer (TNBC) vs non-triple-negative breast cancer (NTNBC) chemotherapy and retrospective after TNBC chemotherapy Retrospective memory (RM) and prospective memory (PM) lesions. Methods Thirty patients with postoperative adjuvant chemotherapy of TNBC and NTNBC in the Department of Oncology, the Second Affiliated Hospital of Anhui Medical University from March 2014 to January 2015 were enrolled in the observation group. The age, educational attainment and physical fitness Sixty healthy female volunteers in the observation group were used as the control group, and were respectively surveyed by mini-mental state examination (MMSE) and RM and PM questionnaires. Results Compared with healthy control group, MMSE, RM and PM scores in the observation group were (27.08 ± 1.37), (17.97 ± 4.34) and (18.78 ± 4.24) points respectively, the differences were statistically significant (t = 2.880, -6.486 and -8.645 respectively, all P <0.05. Compared with NTNBC group, the score of MMSE, RM and PM in TNBC group were (26.50 ± 1.67), (19.30 ± 2.60) and (20.33 ± 3.50) Significance, t values were 3.624, -2.483 and -3.018, respectively, P <0.05. Conclusions Patients with breast cancer have varying degree of RM disorder and PM disorder after chemotherapy, and the damage of RM and PM in patients with TNBC is more significant than that of patients with NTNBC, suggesting that the different expression of hormone receptor may be associated with the heterogeneity of memory impairment after breast cancer chemotherapy related.