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目的了解我院药品不良反应(ADR)发生及引发的相关因素。方法采用描述性研究方法对2006年7月～2007年12月我院298例ADR报告进行分类统计分析。结果298例ADR中,男性多于女性,男女之比为1.36:1;>60a以上老年人有75例,占25.17%;单一用药225例,合并用药73例;ADR程度重度40例,中度186例,轻度72例;对症治疗232例,未进行特殊处理66例;治愈188例,好转110例;因果关系评定为肯定2例,很可能211例,可能95例;抗感染药物引起的ADR占48.52%;其次为中枢神经系统药,占16.57%;皮肤及附件损害最多,占67.78%。结论应加强ADR的监测和ADR知识的宣传,避免或减少其重复发生。
Objective To understand the incidence of adverse drug reactions (ADR) in our hospital and the related factors. Methods Descriptive method was used to classify 298 ADR cases in our hospital from July 2006 to December 2007. Results Among 298 ADRs, there were more males than females, the ratio of men to women was 1.36: 1. There were 75 cases of elderly people over 60 years old, accounting for 25.17% of the total. There were 225 cases of single drug use and 73 cases of combined medication. 186 cases, mild 72 cases; symptomatic treatment of 232 cases, 66 cases without special treatment; 188 cases were cured, improved in 110 cases; causality was rated as 2 cases, probably 211 cases, 95 cases may be; anti-infective drug-induced ADR accounted for 48.52%; followed by the central nervous system drugs, accounting for 16.57%; skin and accessories damage the most, accounting for 67.78%. Conclusion Monitoring of ADR and ADR knowledge should be strengthened to avoid or reduce its recurrence.