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目的:了解南京地区非甾体抗炎药的应用状况及发展趋势,为临床合理用药和新药开发提供参考。方法:采用金额排序和约定日剂量分析(DDD)方法对南京地区非甾体抗炎药的应用情况进行统计分析。结果:南京地区非甾体抗炎药的年用药金额和用药频率(DDDs)均有不同程度的增长,其中2004年的增长幅度最大,分别为24．2％和24．3％。结论:传统的非甾体抗炎药(NSAIDs)依然占主导地位,特异性的COX-2抑制剂迅猛发展、广泛应用,但基于两者的不良反应和广阔的市场需求,研发高效安全的新型解热镇痛药有着良好的前景。
Objective: To understand the application status and development trend of nonsteroidal anti-inflammatory drugs in Nanjing, and to provide reference for clinical rational drug use and new drug development. Methods: The application of non-steroidal anti-inflammatory drugs in Nanjing area was statistically analyzed by the method of order of magnitude and DDD. Results: The annual medication amount and DDDs of NSAIDs in Nanjing all increased to some extent. Among them, the largest increase in 2004 was 24.2% and 24.3% respectively. CONCLUSIONS: Conventional non-steroidal anti-inflammatory drugs (NSAIDs) remain predominant and specific COX-2 inhibitors are rapidly developing and are in widespread use. However, based on their adverse reactions and broad market needs, new types of NSEs are developed Antipyretic analgesics have a good prospect.